2012

Lam TTY, Hon CC, Lemey P, Pybus OG, Shi M, Tun HM, Li J, Jiang J, Holmes EC, Leung FCC. Phylodynamics of H5N1 avian influenza virus in Indonesia. Molecular Ecology In press

Lam TTY, Zhu H, Smith DK, Guan Y, Holmes EC, Pybus OG. The recombinant origin of emerging human norovirus GII.4/2008: intra-genotypic exchange of the capsid P2 domain. Journal of General Virology 93:817-22

Tang J, Nandini S, Lam TT. Influenza. In: Antimicrobial Therapy and Vaccines (Victor Yu, editor) In press

2011

Lam TT, Ip HS, Ghedin E, Wentworth DE, Halpin RA, Stockwell TB, Spiro DJ, Dusek RJ, Bortner JB, Hoskins J, Bales BD, Yparraguirre DR, Holmes EC. Migratory flyway and geographical distance are barriers to the gene flow of influenza virus among North American birds. Ecology Letters 15:24-33

Lam TT, Zhu H, Wang J, Smith DK, Holmes EC, Webster RG, Webby R, Peiris JM & Guan Y. Reassortment events among swine influenza A viruses in China: implications for the origin of the 2009 influenza pandemic. Journal of Virology 85:10279-85

Nelson MI, Tan Y, Ghedin E, Wentworth DE, St George K, Edelman L, Beck ET, Fan J, Lam TT, Kumar S, Spiro DJ, Simonsen L, Viboud C, Holmes EC, Henrickson KJ & Musser JM. Phylogeography of the spring and fall waves of the H1N1/09 pandemic influenza virus in the United States. Journal of Virology 85:828-34

Nelson MI, Lemey P, Tan Y, Vincent A, Lam TT, Detmer S, Viboud C, Suchard MA, Rambaut A, Holmes EC & Gramer M. Spatial dynamics of human-origin H1 influenza A virus in North American swine. PLoS Pathogens 7:e1002077

Cai S, Li J, Wong MT, Jiao P, Fan H, Liu D, Liao M, Jiang J, Shi M, Lam TT, Ren T, Leung FC. Genetic characterization and evolutionary analysis of 4 Newcastle disease virus isolate full genomes from waterbirds in South China during 2003-2007. Veterinary Microbiology 152:46-54

2010

Tee KK*, Lam TT*, Chan YF, Bible JM, Kamarulzaman A, Tong CY, Takebe Y, Pybus OG. Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene. Journal of Virology 84:3339-50

Li R, Fan W, Tian G, Zhu H, He L, Cai J, Huang Q, Cai Q, Li B et al. The sequence and de novo assembly of the giant panda genome. Nature 463:311-7

Lam TT, Hon CC, Tang JW. Use of phylogenetics in the molecular epidemiology and evolutionary studies of viral infections. Critical Reviews in Clinical Laboratory Sciences 47:5-49

Shi M, Lam TT, Hon CC, Murtaugh MP, Davies PR, Hui RK, Li J, Wong LT, Yip CW, Jiang JW, Leung FC. Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses. Journal of Virology 84:8700-11

Shi M, Lam TT, Hon CC, Hui RK, Faaberg KS, Wennblom T, Murtaugh MP, Stadejek T, Leung FC. Molecular epidemiology of PRRSV: a phylogenetic perspective. Virus Research 154:7-17

Yuan J, Hon CC, Li Y, Wang D, Xu G, Zhang H, Zhou P, Poon LL, Lam TT, Leung FC, Shi Z. Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans. Journal of General Virology 91:1058-62

Murtaugh MP, Stadejek T, Abrahante JE, Lam TT, Leung FC. The ever-expanding diversity of porcine reproductive and respiratory syndrome virus. Virus Research 154:18-30

Tang JW, Shetty N, Lam TT, Hon KL. Emerging, novel, and known influenza virus infections in humans. Infectious Disease Clinics of North America 24:603-17

Tang JW, Shetty N, Lam TT. Features of the new pandemic influenza A/H1N1/2009 virus: virology, epidemiology, clinical and public health aspects. Current Opinion in Pulmonary Medicine 16:235-41

2009

Yip CW, Hon CC, Shi M, Lam TT, Chow KY, Zeng F, Leung FC. Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses. Infection, Genetics and Evolution 9:1185-96

2008

Lam TT, Hon CC, Pybus OG, Kosakovsky Pond SL, Wong RT, Yip CW, Zeng F, Leung FC. Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia. PLoS Pathogens 4:e1000130

Lam T, Hon CC, Wang Z, Hui RK, Zeng F & Leung FC. Evolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events. Virus Research 131:271-8

Lam TT, Hon CC, Lam PY, Yip CW, Zeng F, Leung FC. Comments to the predecessor of human SARS coronavirus in 2003-2004 epidemic. Veterinary Microbiology 126:390-3

Hon CC, Lam T, Shi ZL, Drummond AJ, Yip CW, Zeng F, Lam PY, Leung FC. Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus. Journal of Virology 82:1819-26

Hon CC, Lam TT, Yip CW, Wong RT, Shi M, Jiang J, Zeng F, Leung FC. Phylogenetic evidence for homologous recombination within the family Birnaviridae. Journal of General Virology 89:3156-64

2007

Ma CM, Hon CC, Lam T, Li VY, Wong CK, de Oliveira T, Leung FC. Evidence for recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China. Journal of General Virology 88:1733-7

2006

Hon CC, Lam T, Drummond A, Rambaut A, Lee YF, Yip CW, Zeng F, Lam PY, Ng PT, Leung FC. Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B. Journal of Virology 80:8503-9

Room E114

Department of Zoology

University of Oxford

South Parks Road

Oxford

OX1 3PS, UK

(Email)

I study the molecular evolution and epidemiology of RNA and DNA viruses that cause human and animal diseases. My present research focuses on human, avian and swine influenza. I am investigating the evolutionary forces and environmental factors that drive the continuous circulation of H5N1 highly-pathogenic avian influenza in Asia and the Middle East. I am also studying whether the transmission of low-pathogenicity avian influenza in wild birds can be explained by their migration pathways. I aim to identify the adaptation that may underlie viral emergence in new host populations by comparative analyses of influenza genomes.

I also work on several other viruses, including HIV-1, dengue virus, adenoviruses, enterovirus-71, noroviruses, infectious bursal disease virus, infectious salmon anaemia virus, SARS coronavirus, rabies virus, PRRSV, porcine circovirus and the West Nile virus. I am interested in the evolutionary biology and comparative genomics of other organisms, such as the giant panda and the tubercles bacillus.