Katrina Lythgoe

Sir Henry Dale Research Fellow

Department of Zoology

University of Oxford

Peter Medawar Building

South Parks Road

Oxford, OX1 3SY, UK

I apply ecological and evolutionary theory to better predict the evolutionary dynamics of infectious disease in humans and other species, with the ultimate aim of informing public health decisions.  In particular, I am interested in disentangling the, often conflicting, selection pressures acting on pathogens at different ecological levels, and to assess the impact this has on the evolutionary epidemiology of infectious disease.  My approach is inter-disciplinary in nature, including the application and development of evolutionary theory, incorporating immunology into within-host models, using and making sense of next generation sequence data, and applying epidemiological theory. The current focus of my research is on HIV and hepatitis C virus, but the theory I develop has implications for our understanding of infectious disease more widely.

I welcome enquiries from people who would be interested in joining my group either as a postdoc or PhD student.

Research Interests

Lythgoe KA, Gardner A, Pybus OG, Grove J (2017) Short-sighted virus evolution and a germline hypothesis for chronic viral infections. Trends in Microbiology 25:336-48

Doekes HM, Fraser C, Lythgoe KA (2017) Effect of the latent reservoir on the evolution of HIV at the within- and between-host levels. PLOS Computational Biology 13:e1005228

Lythgoe KA, Blanquart F, Pellis L, Fraser C (2016) Large variations in viral load explained by shifting-mosaic metapopulation dynamics. PLOS Biology 14:e1002567

Blanquart F, Grabowski MK, Herbeck J, Nalugoda F, Serwadda D, Eller MA, Robb ML, Gray R, Kigozi G, Laeyendecker O, Lythgoe KA, Nakigozi G, Quinn TC, Reynolds SJ, Wawer MJ, Fraser C (2016) A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda. eLife 5:e20492

Fraser C, Lythgoe K*, Leventhal GE, Shirreff G, Hollingsworth TD, Alizon S, S. Bonhoeffer S* (2014) Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective. Science 343:1243727

van de Vijver DA, Nichols BE, Abbas U, Cambiano V, Eaton J, Glaubius R, Lythgoe KA, Mellors J, Phillips A, Sigaloff KC, Hallett T (2013) Pre-exposure prophylaxis (PrEP) will have a limited impact on the prevalence of HIV-1 drug resistance in sub-Saharan Africa: comparison of mathematical models. AIDS 27:2943-2951

Lythgoe KA, Pellis L, Fraser C (2013) Is HIV short-sighted? Insights from a multi-strain nested model. Evolution 67:2769-2782

Lythgoe KA, Fraser C (2012) New insights into the evolutionary rate of HIV-1 at the within- and between-host levels. Proceedings of the Royal Society B 279:3367-3375

Lythgoe KA, Morrison LJ, Read AF, Barry JD (2007) Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation. Proceedings of the National Academy of Science USA 104:8095-8100

Barry JD, Marcello L, Morrison LJ, Read AF, Lythgoe K, Jones N, Carrington M, Blandin G, Böhme U, Caler E, Hertz-Fowler C, Renauld H, El-Sayed, Berriman M (2005) What the genome sequence is revealing about trypanosome antigenic variation. Biochemical Society Transactions 33:986-989

Lythgoe KA, Chao L (2003)  Mechanisms of coexistence between a bacteria and a bacteriophage in a spatially homogeneous environment. Ecology Letters 6:326-334

Lythgoe KA (2002)  Effects of acquired immunity and mating strategy on the genetic structure of parasite populations. American Naturalist 159:519-529

Lythgoe KA (2000) The coevolution of parasites with host-acquired immunity and the evolution of sex. Evolution 54:1142-1156

Lythgoe KA, AF Read (1998) Catching the Red Queen? The advice of the rose. Trends in Ecology & Evolution 13:473-474

Lythgoe KA (1997) Consequences of gene flow in spatially structured populations. Genetical Research 69:49-60


* denotes equal contributions