Julien Thézé

Post-doctoral Researcher

Department of Zoology

University of Oxford

Peter Medawar Building

South Parks Road

Oxford, OX1 3SY, UK

I am a computational evolutionary biologist with broad interests in viral evolution, genome evolution, mobile genetic element evolution, and ecology. My previous research focused on insect virus macroevolution. My current research focuses on investigating the evolutionary dynamics of human and animal pathogens, combining genetic, spatial and ecological information. My projects involve (i) investigating pathogen cross-species transmission and host shifts, (ii) uncovering the spatio-temporal dynamics of pathogens, (iii) identifying drivers underlying pathogen spread, and (iv) developing methods for pathogen discoveries in animal populations.

Márquez, S, Carrera J, Pullan ST, Lewandowski K, Paz V, Loman N, Quick J, Bonsall D, Powell R, Thézé J, Pybus OG, Klenerman P, Eisenberg J, Coloma J, Carroll MW, Trueba G, Logue CH (2017) First complete genome sequences of Zika virus isolated from febrile patient sera in Ecuador. Genome Announcements 5:e01673-16

Leclercq S*, Thézé J*, Chebbi MA, Giraud I, Moumen B, Ernenwein L, Grève P, Gilbert C, Cordaux R (2016) Birth of a W sex chromosome by horizontal transfer of Wolbachia bacterial symbiont genome. Proceedings of the National Academy of Sciences USA 15036-41

Naccache SN*, Thézé J*, Sardi SI, Somasekar S, Greninger AL, Bandeira AC, Campos GS, Tauro LB, Faria NR, Pybus OG, Chiu CY (2016) Distinct Zika virus lineage in Salvador, Bahia, Brazil. Emerging Infectious Diseases 22:1788-92

Faria NR, Azevedo RD, Kraemer MU, Souza R, Cunha MS, Hill SC, Thézé J, Bonsall MB, Bowden TA, Rissanen I, Rocco IM, Nogueira JS, Maeda AY, Vasami FG, Macedo FL, Suzuki A, Rodrigues SG, Cruz AC, Nunes BT, Medeiros DB, Rodrigues DS, Nunes Queiroz AL, Silva EV, Henriques DF, Travassos da Rosa ES, de Oliveira CS, Martins LC, Vasconcelos HB, Casseb LM, Simith DB, Messina JP, Abade L, Lourenço J, Alcantara LC, Lima MM, Giovanetti M, Hay SI, de Oliveira RS, Lemos PD, Oliveira LF, de Lima CP, da Silva SP, Vasconcelos JM, Franco L, Cardoso JF, Vianez-Junior JL, Mir D, Bello G, Delatorre E, Khan K, Creatore M, Coelho GE, de Oliveira WK, Tesh R, Pybus OG, Nunes MR, Vasconcelos PF (2016) Zika virus in the Americas: early epidemiological and genetic findings. Science 352:345-9

Pybus OG & Thézé J (2016) Hepacivirus cross-species transmission and the origins of the hepatitis C virus. Current Opinion in Virology 16:1-7

Spiri AM*, Thézé J*, Meli ML, Cattori V, Berger A, Steinrigl A, Pybus OG, Hofmann-Lehmann R, Willi B (2016) The genetic diversity and phenotypic associations of feline caliciviruses from cats in Switzerland. Journal of General Virology In press

Trösemeier JH, Musso D, Blümel J, Thézé J, Pybus OG, Baylis SA (2016) Genome sequence of a candidate World Health Organization reference strain for Zika virus for nucleic acid testing. Genome Announcements 4:e00917-16

Thézé J, Lowes S, Parker J, Pybus OG (2015) Evolutionary and phylogenetic analysis of the hepaciviruses and pegiviruses. Genome Biology & Evolution 7:2996-3008

Bézier A, Thézé J, Gavory F, Gaillard J, Poulain J, Drezen JM, Herniou EA (2015) The genome of the nucleopolyhedrosis causing virus from Tipula oleracea (ToNV) sheds new light into the Nudiviridae family. Journal of Virology 85:3008-3025

Thézé J, Takatsuka J, Nakai M, Arif B, Herniou EA (2015) Gene acquisition convergence between Entomopoxviruses and Baculoviruses. Viruses 7:1960-74

Pichon A, Bézier A, Urbach S, Aury J-M, Jouan V, Ravallec M, Guy J, Cousserans F, Thézé J, Gauthier J, Demettre E, Schmieder S, Wurmser F, Sibut V, Poirié M, Colinet D, da Silva C, Couloux A, Barbe V, Drezen J-M, Volkoff A-N (2015) Recurrent DNA virus domestication leading to different parasite virulence strategies. Science Advances 1:e1501150

Thézé J, Leclercq S, Moumen B, Cordaux R, Gilbert C (2014) Remarkable diversity of endogenous viruses in a crustacean genome. Genome Biology & Evolution 6:2129–2140

Thézé J*, Cabodevilla O*, Palma L, Williams T, Caballero P, Herniou EA (2014). Genomic diversity in European Spodoptera exigua multiple nucleopolyhedrovirus isolates. Journal of General Virology 95:2297–2309

Chevignon G, Thézé J, Cambier S, Poulain J, Da Silva C, Bézier A, Musset K, Moreau SJM, Drezen JM, Huguet E (2014). Functional annotation of Cotesia congregata bracovirus: identification of the viral genes expressed in parasitized host immune tissues. Journal of Virology 88:8795-8812

Thézé J, Takatsuka J, Li Z, Gallais J, Arif B, Nakai M, Herniou EA (2013) New insights into the evolution of Entomopoxvirinae from the complete genome sequences of four entomopoxviruses infecting Adoxophyes honmai, Choristoneura biennis, Choristoneura rosaceana and Mythimna separata. Journal of Virology 87:7992-8003

Herniou EA, Huguet EJ, Thézé J, Bézier A, Periquet G, Drezen JM (2013) When parasitic wasps hijacked viruses: genomic and functional evolution of polydnaviruses. Philosophical Transactions of the Royal Society Series B 368:20130051

Bézier A, Louis F, Jancek S, Periquet G, Thézé J, Gyapay G, Musset K, Lesobre J, Lenoble P, Dupuy C, Gundersen- Rindal D, Herniou EA, Drezen JM (2013) Functional Endogenous Viral Elements (EVEs) in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses. Philosophical Transactions of the Royal Society Series B 368:20130047

Thézé J, Bézier A, Periquet G, Drezen JM, Herniou EA (2011) Paleozoic origin of insect large dsDNA viruses. Proceedings of the National Academy of Sciences USA 108:15931-15935

Derrien T, Thézé J, Vaysse A, André C, Ostrander EA, Galibert F, Hitte C (2009) Revisiting the missing protein-coding gene catalog of the domestic dog. BMC Genomics 10:62

Research Interests

Publications

* denotes equal contributions