Julien Thézé

Post-doctoral Researcher

Department of Zoology

University of Oxford

Peter Medawar Building

South Parks Road

Oxford, OX1 3SY, UK

I am a computational evolutionary biologist with broad interests in viral evolution, genome evolution, mobile genetic element evolution, and ecology. My previous research focused on insect virus macroevolution. My current research focuses on investigating the evolutionary dynamics of human and animal pathogens, combining genetic, spatial and ecological information. My projects involve (i) investigating pathogen cross-species transmission and host shifts, (ii) uncovering the spatio-temporal dynamics of pathogens, (iii) identifying drivers underlying pathogen spread, and (iv) developing methods for pathogen discoveries in animal populations.

Naveca FG, Claro I, Giovanetti M, Jesus JG, Xavier J, Iani FC, do Nascimento VA, de Souza, VC, Silveira PP, Lourenço J, Santillana M, Kraemer MUG, Quick J, Hill SC, Thézé J, Carvalho RDO, Azevedo V, Salles FCS, Nunes MRT, Lemos PS, Candido DS, Pereira GC, Oliveira MA, Meneses CA, Maito RM, Cunha CR, Campos DPS, Castilho MC, Siqueira TC, Terra TM, de Albuquerque CF, da Cruz LN, Abreu AL, Martins DV, Simoes DS, Aguiar RS, Sabino EC, Pybus OG, Loman N, Okumoto O, Alcântara LCJ, Faria NR (2019) Genomic, epidemiological and digital surveillance of Chikungunya virus in the Brazilian Amazon. PLOS Neglected Tropical Diseases In press

Hill SC, de Vasconcelos JN, Gutierrez B, Thézé J, Jandondo D, Neto Z, Mirandela M, Sebastião CS, Cândido ALM, Clemente C, da Silva SP, de Oliveira T, Pybus OG, Faria NR, Afonso JM (2019) Early genomic detection of the cosmopolitan genotype of dengue virus 2 in Angola, 2018. Emerging Infectious Diseases In press

Thézé J, Li T, du Plessis L, Bouquet J, Kraemer MU, Somasekar S, Yu G, de Cesare M, Balmaseda A, Kuan G, Harris E, Wu CH, Ansari AM, Bowden R, Faria N, Yagi S, Messenger S, Brooks T, Stone M, Bloch E, Busch M, Muñoz-Medina J, González-Bonilla C, Wolinsky S, López S, Arias C, Bonsall D, Chiu CY, Pybus OG (2018) Genomic epidemiology reconstructs the introduction and spread of Zika virus in central America and Mexico. Cell Host & Microbe 23:855-64

Faria NR, Kraemer MUG, Hill SC, Goes de Jesus J, de Aguiar RS, Iani FCM, Xavier J, Quick J, du Plessis L, Dellicour S, Thézé J, Carvalho RDO , Baele G, Wu C-H, Silveira PP, Arruda MB, Pereira MA, Pereira GC, Lourenço J, Obolski U, Abade L, Vasylyeva TI, Giovanetti M, Yi D, Weiss DJ, Wint GRW, Shearer FM, Funk S, Nikolai B, Fonseca V, Adelino TER, Oliveira MAA, Silva MVF, Sacchetto L, Figueiredo PO, Rezende IM, Mello EM, Said RFC, Santos DA, Ferraz ML, Brito MG, Santana LF, Menezes MT, Brindeiro RM, Tanuri A, dos Santos FCP, Cunha MS, Nogueira JS, Rocco IM, da Costa AC, Komninakis SCV, Azevedo V, Chieppe AO, Araujo ESM, Mendonça MCL, dos Santos CC, dos Santos CD, Mares-Guia AM, Nogueira RMR, Sequeira PC, Abreu RG, Garcia MHO, Abreu AL, Okumoto O, Kroon EG, de Albuquerque CFC, Lewandowski K, Pullan ST, Carroll M, de Oliveira T, Sabino EC, Souza RP, Suchard MA, Lemey P, Trindade GS, Drumond BP, Filippis AMB, Loman NJ, Cauchemez S, Alcantara LCJ, Pybus OG (2018) Genomic and epidemiological monitoring of yellow fever virus transmission potential. Science 361:894–99

Thézé J, Lopez-Vaamonde C, Cory JS, Herniou EA (2018) Biodiversity, evolution and ecological specialization of baculoviruses: a treasure trove for future applied research. Viruses 10:366

Lu J, Raghwani J, Wu J, Pryce R, Bowden TA, Thézé J, Huang S, Song Y, Zou L, Liang L, Bai R, Jin Y, Zhou P, Kang M, Yi L, Pybus OG, Ke C (2018) Molecular evolution, diversity and adaptation of H7N9 viruses in China during 2013-2017. Emerging Infectious Diseases 24:1795-1805

Zepeda Mendoza ML, Xiong Z, Escalera-Zamudio M, Runge AK, Thézé J, Streicker D, Frank HK, Loza-Rubio E, Liu S, Ryder OA, Castruita JAS, Katzourakis A, Taboada B, Löber U, Pybus OG, Li Y, Rojas-Anaya E, Bohmann K, Baez AC, Arias CF, Liu S, Greenwood AD, Bertelsen MF, White NE, Bunce M, Zhang G, Sicheritz-Pontén T, Gilbert MTP (2018) Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat. Nature Ecology & Evolution 2:659–68

Vasylyeva TI, Liulchuk M, Friedman SR, Sazonova I, Faria NR, Katzourakis A, Babii N, Scherbinska A, Thézé J, Pybus OG, Smyrnov P, Mbisa JL, Paraskevis D, Hatzakis A, Magiorkinis G (2018) Molecular epidemiology reveals the role of war in the spread of HIV in Ukraine. Proceedings of the National Academy of Sciences USA In press

Márquez, S, Carrera J, Pullan ST, Lewandowski K, Paz V, Loman N, Quick J, Bonsall D, Powell R, Thézé J, Pybus OG, Klenerman P, Eisenberg J, Coloma J, Carroll MW, Trueba G, Logue CH (2017) First complete genome sequences of Zika virus isolated from febrile patient sera in Ecuador. Genome Announcements 5:e01673-16

Charlys da Costa A, Thézé J, Komninakis SC, Sanz-Duro RL, Felinto MR, Moura LC, Barroso IM, Santos LEC, Nunes MA, Moura AA, Lourenço J, Deng X, Delwart EL, Guimarães MR, Pybus OG, Sabino EC, Faria NR (2017) Spread of Chikungunya Virus East/Central/South African Genotype in Northeast Brazil. Emerging Infectious Diseases 23:1742-44

Leclercq S*, Thézé J*, Chebbi MA, Giraud I, Moumen B, Ernenwein L, Grève P, Gilbert C, Cordaux R (2016) Birth of a W sex chromosome by horizontal transfer of Wolbachia bacterial symbiont genome. Proceedings of the National Academy of Sciences USA 15036-41

Naccache SN*, Thézé J*, Sardi SI, Somasekar S, Greninger AL, Bandeira AC, Campos GS, Tauro LB, Faria NR, Pybus OG, Chiu CY (2016) Distinct Zika virus lineage in Salvador, Bahia, Brazil. Emerging Infectious Diseases 22:1788-92

Faria NR, Azevedo RD, Kraemer MU, Souza R, Cunha MS, Hill SC, Thézé J, Bonsall MB, Bowden TA, Rissanen I, Rocco IM, Nogueira JS, Maeda AY, Vasami FG, Macedo FL, Suzuki A, Rodrigues SG, Cruz AC, Nunes BT, Medeiros DB, Rodrigues DS, Nunes Queiroz AL, Silva EV, Henriques DF, Travassos da Rosa ES, de Oliveira CS, Martins LC, Vasconcelos HB, Casseb LM, Simith DB, Messina JP, Abade L, Lourenço J, Alcantara LC, Lima MM, Giovanetti M, Hay SI, de Oliveira RS, Lemos PD, Oliveira LF, de Lima CP, da Silva SP, Vasconcelos JM, Franco L, Cardoso JF, Vianez-Junior JL, Mir D, Bello G, Delatorre E, Khan K, Creatore M, Coelho GE, de Oliveira WK, Tesh R, Pybus OG, Nunes MR, Vasconcelos PF (2016) Zika virus in the Americas: early epidemiological and genetic findings. Science 352:345-9

Pybus OG & Thézé J (2016) Hepacivirus cross-species transmission and the origins of the hepatitis C virus. Current Opinion in Virology 16:1-7

Spiri AM*, Thézé J*, Meli ML, Cattori V, Berger A, Steinrigl A, Pybus OG, Hofmann-Lehmann R, Willi B (2016) The genetic diversity and phenotypic associations of feline caliciviruses from cats in Switzerland. Journal of General Virology In press

Trösemeier JH, Musso D, Blümel J, Thézé J, Pybus OG, Baylis SA (2016) Genome sequence of a candidate World Health Organization reference strain for Zika virus for nucleic acid testing. Genome Announcements 4:e00917-16

Thézé J, Lowes S, Parker J, Pybus OG (2015) Evolutionary and phylogenetic analysis of the hepaciviruses and pegiviruses. Genome Biology & Evolution 7:2996-3008

Bézier A, Thézé J, Gavory F, Gaillard J, Poulain J, Drezen JM, Herniou EA (2015) The genome of the nucleopolyhedrosis causing virus from Tipula oleracea (ToNV) sheds new light into the Nudiviridae family. Journal of Virology 85:3008-3025

Thézé J, Takatsuka J, Nakai M, Arif B, Herniou EA (2015) Gene acquisition convergence between Entomopoxviruses and Baculoviruses. Viruses 7:1960-74

Pichon A, Bézier A, Urbach S, Aury J-M, Jouan V, Ravallec M, Guy J, Cousserans F, Thézé J, Gauthier J, Demettre E, Schmieder S, Wurmser F, Sibut V, Poirié M, Colinet D, da Silva C, Couloux A, Barbe V, Drezen J-M, Volkoff A-N (2015) Recurrent DNA virus domestication leading to different parasite virulence strategies. Science Advances 1:e1501150

Thézé J, Leclercq S, Moumen B, Cordaux R, Gilbert C (2014) Remarkable diversity of endogenous viruses in a crustacean genome. Genome Biology & Evolution 6:2129–2140

Thézé J*, Cabodevilla O*, Palma L, Williams T, Caballero P, Herniou EA (2014). Genomic diversity in European Spodoptera exigua multiple nucleopolyhedrovirus isolates. Journal of General Virology 95:2297–2309

Chevignon G, Thézé J, Cambier S, Poulain J, Da Silva C, Bézier A, Musset K, Moreau SJM, Drezen JM, Huguet E (2014). Functional annotation of Cotesia congregata bracovirus: identification of the viral genes expressed in parasitized host immune tissues. Journal of Virology 88:8795-8812

Thézé J, Takatsuka J, Li Z, Gallais J, Arif B, Nakai M, Herniou EA (2013) New insights into the evolution of Entomopoxvirinae from the complete genome sequences of four entomopoxviruses infecting Adoxophyes honmai, Choristoneura biennis, Choristoneura rosaceana and Mythimna separata. Journal of Virology 87:7992-8003

Herniou EA, Huguet EJ, Thézé J, Bézier A, Periquet G, Drezen JM (2013) When parasitic wasps hijacked viruses: genomic and functional evolution of polydnaviruses. Philosophical Transactions of the Royal Society Series B 368:20130051

Bézier A, Louis F, Jancek S, Periquet G, Thézé J, Gyapay G, Musset K, Lesobre J, Lenoble P, Dupuy C, Gundersen- Rindal D, Herniou EA, Drezen JM (2013) Functional Endogenous Viral Elements (EVEs) in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses. Philosophical Transactions of the Royal Society Series B 368:20130047

Thézé J, Bézier A, Periquet G, Drezen JM, Herniou EA (2011) Paleozoic origin of insect large dsDNA viruses. Proceedings of the National Academy of Sciences USA 108:15931-15935

Derrien T, Thézé J, Vaysse A, André C, Ostrander EA, Galibert F, Hitte C (2009) Revisiting the missing protein-coding gene catalog of the domestic dog. BMC Genomics 10:62

Research Interests

Publications

* denotes equal contributions