Authors: Samir Bhatt & Oliver Pybus

Latest version: 1.0

Download program & manual (Adapt-A-Rate

This program estimates the rate of adaptive fixation in a population from sequences sampled at different points in time. It uses a population genetic method that is based on the MacDonald-Kreitman test. See the publications below for details.


Bhatt S, Holmes EC, Pybus OG (2011) The genomic rate of molecular adaptation of the human influenza A virus. Molecular Biology & Evolution 28:2443-51

Bhatt S, Katzourakis A, Pybus OG (2010) Detecting natural selection in RNA virus populations using sequence summary statistics. Infection Genetics & Evolution 10:421-30